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How Does ZYBAN Work?
ZYBAN is the first non-nicotine, oral medication (a pill) that is FDA-approved as an aid to smoking cessation. While it is unclear exactly how ZYBAN works, it is thought to act on the part of your brain that is addicted to the ingredients in cigarettes. ZYBAN helps decrease your cravings and withdrawal symptoms and your desire to smoke.

 

 

Where to Get Smoking Cessation Support Information
Many people who are quitting smoking find it helpful to speak with a professional who can give them guidance.

You may want to talk about your reasons for quitting or the things that are giving you trouble. The National Cancer Institute is a governmental agency that provides free, up-to-date information to the public. It has a toll-free line that puts you in touch with information specialists that can speak with you about quitting smoking. Although it's called the Cancer Information Service, the specialists are trained to discuss quitting smoking with any caller.

To access this service, call 1-800-422-6237, and you will reach your regional office of the National Cancer Institute's Cancer Information Service. It is open Monday through Friday from 9 AM until 4:30 PM. Remember, this service is free to the public.

You may also want to find out about support groups or other programs in your area that might help you quit smoking. The American Lung Association has a program called Freedom From Smoking®. To learn more about the cost of this program or to find out when meetings will be held in your town, call 1-800-LUNG-USA (1-800-586-4872). The American Cancer Society also has a program designed to help people stop smoking. Former smokers usually lead this program. You can reach the American Cancer Society at 1-800-227-2345. Ask when sessions of the Fresh Start program will be held in your local area.
 

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Zyban Effectiveness
In the study involving the patch, patients treated with Zyban had significantly higher four-week quit rates than those treated with the patch. Patients treated with the combination of Zyban and the patch had significantly higher quit rates than those treated with the patch alone. Quit rates with combination therapy, while higher, were not statistically higher than quit rates with Zyban alone. The four-week quit rates from this study were 23% for placebo; 36% for the patch; 49% for Zyban; and 58% for the combination of Zyban and the patch.


Results from the two studies demonstrated that patients treated with Zyban 300 mg/day had more than a two-fold chance of quitting than patients treated with placebo. Quit rates in clinical trials are affected by the population selected and may be lower for the general population.


For many patients, treatment with Zyban reduced withdrawal symptoms. Withdrawal symptoms showing the most pronounced reductions were: irritability, frustration or anger, anxiety, difficulty concentrating, restlessness, and depressed mood or negative affect. In patients treated with Zyban, there also was evidence of a reduction in craving for cigarettes or urge to smoke.


The most common side effects associated with the use of Zyban are dry mouth and insomnia. These side effects are generally mild and often disappear after a few weeks.

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